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Procedures that can be performed with local anesthesia, minimal sedation, neuraxial techniques, or peripheral nerve blocks may offer risk reduction when clinically appropriate

Br J Dermatol 130(4):540541 Habre M, Ortonne N, Colin A, Meningaud JP, Chosidow O, Wolkenstein P, Valeyrie-Allanore L (2016) Facial scars following toxic epidermal necrolysis: role of adnexal involvement

However, when HepaRG stem-cell derived human hepatocytes were subjected to APAP, the same mechanisms of hepatotoxicity were demonstratedstarting with GSH depletion and moving through protein adduct formation, superoxide and peroxynitrite formation and lysosomal iron uptake into mitochondria

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