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DGEA (Asp-Gly-Glu-Ala) is a recognition motif used by type I collagen to bind to 2 1 integrin [165]

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Rapamycin exerts anti-ferroptotic effects by decreasing transferrin receptor expression, reducing cellular iron content, and activating the iron-regulated protein-1/2 (Irp1/2) system, potentially compensating for transferrin downregulation to maintain iron homeostasis (69)

Scavenges reactive oxygen species (ROS) Protects mitochondrial membranes Preserves ATP synthesis and cellular vitality Beyond antioxidation, glutathione modulates immune responses and suppresses excessive inflammatory signaling, contributing to tissue protection and homeostatic regulation