Together, they represent the kind of systems-based prevention that has a much stronger foundation than any single brain hack. The bottom line GLP-1 medications are interesting in the brain-health conversation because metabolism, vascular health, inflammation, and cognitive aging are connected
Other Antidepressants and Weight Gain Certain antidepressant classes are more likely to cause weight gain: Tricyclics (nortriptyline, amitriptyline) and MAOIs (tranylcypromine, phenelzine) SSRIs over long-term use (especially paroxetine
All are compounded formulations - not FDA-approved branded products
Links mentioned in this episode Perimenopause weight loss plan Insulin resistance episode: what labs to check Perimenopause weight loss episode Two-part sleep series (why sleep shifts appetite, cortisol, and metabolic health): Part 1, Part 2 Thyroid deep dives with McCall McPherson (thyroid panels and GLP-1 considerations)
Medications that mimic this hormone help enhance these natural signals, which can lead to reduced appetite, improved blood sugar control, and better portion awareness