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Unlike subcutaneous fat, visceral fat is highly metabolically active, with greater blood flow, higher concentrations of glucocorticoid receptors, and increased sensitivity to lipolytic (fat-breaking) hormones

What we know from TRIUMPH-4 (blood pressure through 68 weeks): Systolic BP: -14.0 mmHg (12mg dose, efficacy estimand) Diastolic BP: -4.3 mmHg average reduction These reductions persisted even as weight loss plateaued in the final weeks, suggesting blood pressure benefits may be partially independent of weight possibly due to direct GLP-1 and glucagon receptor effects on vascular function

They are associated with slower glucose absorption compared with refined carbohydrate foods

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Gallian P, Pouchol E, Djoudi R, Lhomme S, Mouna L, Gross S, et al