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In earlier clinical trials, IGV-001 demonstrated good tolerance and safety (NCT02507583)

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The patient no longer remembered or understood the improvement he had experienced with hyperbaric treatment and refused all attempts at treatment, except for a 1-h session in early June 2020

Paeonol also inhibited melanin transfer and PAR-2 activating peptide SLIGRL-induced melanin transfer during co-culture of melanocytes and keratinocytes ( 2.4 Others 2.4.1 Capsaicine Capsaicin, a unique alkaloid primarily found in Capsicum fruits (151), has been extensively investigated for its antioxidant, anti-inflammatory, analgesic, and anticancer properties (152155)