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In addition, the guidelines were the first time the AAP issued comprehensive recommendations for how pediatricians should approach obesity treatment

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Funnel plots also reflected a considerable publication bias (Fig

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Polley pointed out that even patients with similar clinical profiles might prioritize different aspects of their health or quality of life

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Common Off-Label Uses Polycystic Ovary Syndrome (PCOS) Some providers prescribe GLP-1s to improve insulin resistance, weight-related symptoms, and menstrual regularity Small studies show potential benefits Infertility / Preconception Support Off-label use in people trying to conceive (especially those with an elevated BMI and/or insulin resistance)

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