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Search Strategy A comprehensive search of PubMed/MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL) was performed from database inception through the final search date

The 1.6 mg bi-weekly dose can be split into smaller daily doses (approximately 0.45 mg daily) due to the peptide's short half-life

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On June 25, 2025, the Office of the Inspector General (OIG) of the U.S

Proteins, including tight junction proteins such as the claudins and occludins control paracellular permeability, defined as the conductance of water and small solutes through the spaces between adjacent epithelial cells [33, 34]