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Recently, the development of GLP-1 agonists that show promise against obesity-associated disease named as Sciences 2023 Breakthrough ( Due to the different routes of administration and different GLP-1R analogs, GLP-1 and GLP-1R may be involved in different signaling pathways that directly or indirectly send signals to the central nervous system to inhibit ingestion and regulate eating behaviors by the nociceptors

RhGLP-1 also decreased the level of cleaved caspase-3 and increased the expression of excitatory amino acid transporter 2 (EAAT2) and the ratio of Bcl-2/Bax from the level of protein (90)