One injection per week is easier to maintain over months and years than two, three, or seven injections per week
Metformin reduces hepatic glucose production, improves insulin sensitivity, and may have modest effects on appetite and weight
Retatrutide is one of the most extensively studied incretin-family peptides published in the past five years
However, it is important to take into account the possibility that binding of JWU-A021 to TRPA1 channels leads to membrane depolarization and action potential generation, thereby stimulating additional Ca 2+ influx through VDCCs
In this trial, participants subcutaneously received retatrutide (1.0 mg, 4.0 mg, 8.0 mg, 12 mg) or placebo once weekly for 48 weeks