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When this window is breached, the drug's ability to activate GLP-1 and GIP receptorsthe mechanism responsible for appetite suppression and improved metabolic functionbecomes compromised
10.1111/j.1476-5381.2011.01482.x [DOI] [PMC free article] [PubMed] [Google Scholar] Dang V
Some rodent studies used oral gavage with reported effects, supporting the plausibility of systemic activity via the oral route
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