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How Your Genetics Relate to GLP-1 Pathways Your genes determine how efficiently your GLP-1 and GIP receptors respond to semaglutide, and how effectively your body regulates appetite-control peptides like leptin and melanocortin

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Whatever the reason you came off a GLP-1 medication, you're far from alone: Within two years, nearly three in four people taking these medications for weight loss stop, according to a 2025 study of 125,000 patients

Its also slightly less potent for A1C reduction (average blood glucose over the past two to three months) in people with type 2 diabetes