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It's the absence of evidence in either direction

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J Physiol Pharmacol 66:581590 Soares de Moura R, Rios AA, de Oliveira LF et al (2001) The effects of nitric oxide synthase inhibitors on the sedative effect of clonidine

Notably, interventions aimed at eliminating senescent cells using genetic approaches or dasatinib plus quercetin (D+Q) yielded significant reductions in aortic aging markers and calcification in aging and atherosclerotic mice