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Minipigs, despite physiological similarities to humans, frequently display disproportionately high intestinal motility or mucus thickness, leading to over- or underestimation of peptide absorption (Hatton et al., 2015
For more information: Mark Taylor, MD, can be reached at [email protected].
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A comparative study on the physiochemical properties of SAH peptides with different types of crosslinks conducted by Tian and co-workers [124] showed that when stapled at the same position of a peptide sequence targeting the estrogen receptor (ER) coactivator, the lactam and all-HCS peptides exhibited the highest helical contents, followed by the triazole and the m -xylene crosslink, the helicity of vinyl sulfide stapled peptides is slightly higher than the m -xylene crosslink
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