This alternative route shows why highly lipophilic compounds (with log P values above 5) show better bioavailability through lymphatic transport
[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Gauthier-Coles G., Fairweather S.J., Broer A., Broer S
Among these, ACSL4 catalyses the activation of PUFAs, such as arachidonic acid, into their corresponding acyl-CoA derivatives, whereas LPCAT3 incorporates these activated PUFAs into membrane phospholipids through phospholipid remodelling
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6.6 In vitro approaches Another approach for the detection of potential sensitizing capacity that would not rely on in vivo animal or human testing is directed towards the construction of in vitro experimental models that reflect accurately some pivotal event during skin sensitization