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This phenomenon is known as metabolic reprogramming, which is necessary for malignant tumour progression, including aggressiveness and metastasis
74 Chronic overnutrition, a sedentary lifestyle and IR in adipose tissue can directly lead to the production and accumulation of excess toxic lipid products (such as diacylglycerol, ceramides, and NEFAs), and the metabolites can aggravate the ectopic lipid deposition through some signaling pathways (such as mTOR and notch)
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