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These symptoms may relate to the medication's effects on the gastrointestinal system, represent a physiological response to weight loss and metabolic changes, or reflect semaglutide's known small effect on increasing heart rate

Portions that used to satisfy you may feel small again, and cravings for high calorie foods can come back

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Through neural pathways as well as via receptor-mediated effects, GLP-1 reduces postprandial hyperglycemia by stimulation of insulin secretion, suppression of glucagon release, inhibition of gastric emptying and small intestinal peristalsis, and induction of satiety which limits meal size [17]

By 8-12 weeks, the majority of patients who initially experienced gastrointestinal symptoms find them minimal or absent