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*Additional reporting done by Kelsey Kunik, RDN

During autophagy induction, global and promoter-specific H4K16ac levels, including those at ATG7 and ULK1 , decrease due to hMOF downregulation, indicating that reduced hMOF activity limits excessive autophagy and facilitates proper autophagic flux

Melatonin could resolve hyper-inflammatory conditions in COVID-19 and PASC by down-regulating proinflammatory cytokines (i.e., TNF-, IL-1, IL-6, and IL-8) and increasing anti-inflammatory cytokines such as IL-10 660,661

doi: 10.1126/scitranslmed.adk8230 22 ChenLLoWHuangHWuH

Meiboom S, Gill D (1958) Modified spin-echo method for measuring nuclear relaxation times