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A possible explanation for the role of PAPP-A is through increasing the levels of IGFs and their downstream signaling pathway (156)

3.2.2.1 Omega-3 fatty acids Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential polyunsaturated fatty acids (PUFAs) recognized for their anti-inflammatory properties

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This has made it a cornerstone of many longevity-focused protocols