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For example, oxidative stress triggers dissociation of the Trx:ASK1 complex by oxidizing thioredoxin, resulting in the activation of ASK1 (Tobiume et al ., 2002)

10.1111/jcmm.12001 69 JantasD.LasoW

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In hypoxic conditions, ECs initiate a pro-angiogenic response that causes loss of barrier function and facilitates cardiac immune cell infiltration and subsequent inflammation and edema [71, 72]

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