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6 According to the WHO global burden of disease report, more than 4 million people die each year as a result of overweight or obesity, and median survival is reduced by 2 years to 4 years for those with a BMI of 30 kg/m 2 to 35 kg/m 2 , and by 8 years to 10 years for those with a BMI of 40 kg/m 2 to 50 kg/m 2

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The overexpression of Parkin in cortical neurons has been demonstrated to increase the levels of PGC-1 and mtDNA copy number (Zheng et al., 2017)