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Some formulation vehicles cause mild burning, tingling, or discomfort under the tongue

Reduces Liver Fat: In individuals with MASLD, retatrutide leads to profound reductions (over 80% at high doses) in liver fat and often normalization of hepatic fat contentchanges strongly linked to improved metabolic health 1

By the end of Q1 2026, Lilly had captured over 60% of the U.S

Clinical trials have consistently demonstrated that retatrutide, in combination with lifestyle modifications, leads to significant and sustainable weight loss

People with chronic kidney disease or frailty may have specific protein requirements and should discuss individual targets with a registered dietitian