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A: Pituitary GH release hepatic IGF-1 production effects on protein synthesis, fat metabolism, and cellular regeneration across multiple tissues

A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)

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doi:10.1136/heartjnl-2024-324170 8

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