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In cases of overdose of alpha lipoic acid, some patients have developed lactic acidosis, hemodynamic instability, rhabdomyolysis, renal dysfunction, and multiorgan failure, but symptoms of neurologic, cardiac and renal dysfunction generally predominate and liver injury may be the result of shock and ischemia

3.4.2 Nrf2 activators Studies have demonstrated that Nrf2-ARE signaling pathway also plays a core role in the regulation of mitochondrial dynamics