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Of the six IGFBPs, IGFBP-3 is the major binding protein for IGF-1 that modulates its biological effects (233)

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Warnings and Precautions 5.1 Risk of Thyroid C-Cell Tumors In both sexes of rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) in a 2-year study at clinically relevant plasma exposures [see Nonclinical Toxicology (13.1)]

Possible temporary redness post-treatment

The nasal epithelium is more permeable than the gut, which is why intranasal delivery is used clinically for peptides like desmopressin (1-deamino-8-D-arginine vasopressin) and calcitonin