Regulatory hurdles: Approval for novel indications (Alzheimers, neurodegenerative diseases) requires very high bar: long follow-ups, clinically meaningful endpoints, safety
3.5 Rapid Weight Loss and Lean Mass Reduction Weight loss during GLP-1 therapy includes: Adipose tissue Lean body mass Data from obesity trials indicate that without resistance training and adequate protein intake, a meaningful proportion of weight lost may be lean mass. Reduced protein intake may indirectly influence: Iron intake Zinc intake B12 intake This creates a secondary nutrient risk pathway unrelated to absorption but related to dietary composition
And it would be filled by legitimate state-licensed pharmacies. Howard Sklamberg, a former FDA deputy commissioner, rejected the broadest version of that harm-reduction argument
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The aging process affects the stomachs ability to produce intrinsic factor, a protein necessary for B12 absorption, explains why older adults need regular shots