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Movements of Lurcher mice are ataxic, they show typical retropulsion and instability, which can be resemble that of human patients [121, 137, 139, 142,143,144,145,146,147,148]

Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation

Currently, a 52-week Phase 2 clinical trial (NCT05669599) is underway for the overweight and obese population to further evaluate the safety and long-term efficacy of AMG133

Semaglutide is available under different brand names, such as Ozempic and Wegovy

According to the MHRA SmPC, Ozempic is initiated at 0.25 mg once weekly for four weeks, serving as a dose-escalation period rather than a therapeutic dose