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Importantly, as the chief brain source of APOE, astrocytes, especially those expressing the APOE4 allele, promote A aggregation, tau pathologies, BBB breakdown, and cerebrovascular dysfunctions (Wang M

Its half-life is approximately five days, meaning it takes about five days for half the dose to be eliminated from the body

Two to four weeks of preparation is ideal

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The patients had an average glycated hemoglobin (HbA1c) level of 8.28% at the beginning of the trial