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The growing popularity of GLP-1 receptor agonists, especially semaglutide (Ozempic, Wegovy), has been accompanied by considerable social media attention and discussion, from which thorough analyses of user-generated data have emerged highlighting reductions in alcohol motivation, decreased drinking behavior, and altered subjective responses to alcohol (Arillotta et al

As weight decreases, many users experience reductions in blood pressure, improved lipid profiles, and lowered markers of cardiovascular risk

They are generally well-tolerated, weight neutral and do not increase the risk of hypoglycemia

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406 Therefore, endogenous GLP-1R signaling in astrocytes plays a critical role in maintaining mitochondrial homeostasis and is dependent on FGF21 to effectively regulate glucose metabolism