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Therefore, it can be considered as one of the major causes of HT that the intestinal barrier function is damaged in the presence of inflammation, and the increased intestinal permeability leads to the antigen that could not pass through the intestinal barrier entering the systemic circulation and activating the immune system, and the generated antibody attacking the thyroid tissue [86]

Nikbakhtian S, Reed AB, Obika BD, et al

Using a PCPA-induced insomnia mouse model, researchers assessed its impact on neurotransmitters like 5-HT, glutamate, dopamine, and melatonin