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18 HeM.JinL.WangF.WangX.YouY.HeH.et al

detailed pre-clinical and clinical studies of the candidate are provided in Supplementary Table S4

As early as 1940, Brewer showed that the absence of trace oxygen was not sufficient for growing strict anaerobes and developed a medium based on sodium thioglycollate, D-glucose (dextrose) and agar 18

CPAP therapy can be cumbersome and uncomfortable, so recommendations for CPAP are generally reserved for patients who experience excessive daytime sleepiness, those with comorbid hypertension, and those for whom their sleep disruption affects their quality of life