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The most commonly reported adverse events were gastrointestinal disorders and hypoglycemia in patients with type 2 diabetes concurrently using sulfonylureas, metformin, and/or SGLT-2 inhibitors

Animal data Reproduction studies have been performed in rats at 20 mg/kg/day (0.13 times the maximum recommended human daily dose of 1,500 mg/day based on body surface area comparison) rabbits at 20 mg/kg/day (0.26 times the maximum recommended human daily dose, based on body surface area comparison), and mice at 170 mg/kg/day (0.6 times the maximum recommended human daily dose based on body surface area comparison) with no evidence of impaired fertility or harm to the fetus due to the drug

All current use of retatrutide remains strictly research-use-only.

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The dopamine D5 receptor may play an important role in increasing the permeability of duodenal epithelial cells and protecting the colonic mucosa (Li et al., 2019)