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The regulation of platelet activation, thrombosis and platelet-mediated inflammation by GLP-1RAs is possibly mediated by GLP1Rs expressed on human platelets and represents another potential mechanism for reduced atherothrombotic events [64,65,66]

It is also integral to energy metabolism, as it acts as a cofactor in the conversion of food into usable energy at the cellular level

This means oral doses must be higher than injectable equivalents to achieve similar clinical effects

However, systematic studies are needed to clarify whether BAMs participate in OA development via the gut-joint axis, that is, via a ferroptosis-modulating mechanism

The three peptides address different phases of the healing cascade