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Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM (2007) Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
The topical application of propolis has further been shown to enhance the cutaneous wound healing of diabetic ulcers experimentally induced in mice by promoting TGF-/SMAD-mediated collagen production [72]
Thus, insulin might stimulate hepatic fatty deposition and liver injury by blocking GLP-1R mediated hepatic lipolysis
The improvement in A1C was generally consistent across subgroups defined by gender, age, race, baseline BMI, baseline A1C, or duration of disease