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This review explores the biology of aging, the role of senescent cells in AD pathology, and various senotherapeutic approaches such as senolytics, dampening the SASP (senescence associated secretory phenotype), senescence pathway inhibition, vaccines, and prodrugs

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A reduction in methionine and SAM in T cells causes the loss of H3K79me2, downregulates the expression of STAT5, and impairs the antitumor immunity of CD8 + T cells [259]