Chemical Structure and Composition of AHK-Cu Peptide AHK-Cu is a tiny synthetic tripeptide that is made up of three amino acids: alanine (A), histidine (H), and lysine (K)
This D-amino acid substitution introduces conformational rigidity within the pharmacophore core (His-D-Phe-Arg-Trp) and significantly increases binding affinity across melanocortin receptor subtypes compared to both -MSH and MT-1
TK, PH and KB are employed at Boehringer Ingelheim Pharma GmbH & Co
[DOI] [PubMed] [Google Scholar] 5.Patoulias D., Popovic D.S., Stoian A.P., Janez A., Sahebkar A., Rizzo M
[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Cao Z.-Y., Liu Y.-Z., Li J.-M., Ruan Y.-M., Yan W.-J., Zhong S.-Y., Zhang T., Liu L.-L., Wu R., Wang B., et al