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Yes, for the vast majority of people

Endogenous antioxidants are proteins and polypeptides that are synthesized in the cell while exogenous antioxidants are obtained from the ingestion of fruits and vegetables

The immune cells, particularly memory T cells, are trapped in a state of hyperproliferation and chronic activation, generating immense amounts of oxidative waste

Animal As a senolytic, FOXO4-DRI carries mechanism-specific theoretical risks discussed in the senescence literature including disruption of beneficial senescence surveillance and off-target effects on stem-cell populations that share features with senescent cells and senolytic translation from mouse to human has a history of failures

Stone J, Johnstone DM, Mitrofanis J, ORourke M