In addition to many of the symptoms we frequently see associated with hyper- and hypothyroidism, Hashimotos commonly presents with: Anxiety Depression Weight gain Mood swings Fatigue Brain fog Cold hands and feet Gastrointestinal issues Food sensitivities I personally experienced irritable bowel syndrome (IBS), anxiety, and advanced carpal tunnel in both hands, which required me to wear wrist braces
It acts on three hormone pathways at once GLP-1, GIP and glucagon receptors to reduce appetite, slow stomach emptying, and increase energy expenditure
Tirzepatide may be more effective on average than semaglutide, with one study showing a 22.5% reduction in body weight over 72 weeks [7]
They called it the "hypodipsic effect," a reduction in the desire to drink that is independent of food intake effects
Its long half-life means the medication remains active in blood and tissues for weeks, continuing to influence appetite, blood sugar, and lab values well after the last dose