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showed that, in a microenvironment deprived of glutamine, due to glutamine addiction in clear cell renal cell carcinoma (ccRCC), tumor-associated macrophages (TAMs) promote an immunosuppressive microenvironment [154]

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doi: 10.4155/tde-2018-0025

However, despite the plethora of observations regarding ROS and ATG, the only direct observation on the involvement of signal transduction mechanisms regulating self-digestion upon thiol/disulfide changes was evidenced in yeasts (Deffieu et al., 2009)