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Notably, this category includes domperidone

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In 2022, before being diagnosed, she lost 75 pounds over 10 months through diet and exercise alone

Additionally, mice with a cre-inducible -cell KO of PC1/3 (although the extent to which intestinal and CNS PC1/3 expression was intact is unknown) had reduced levels of GLP-1 in the islet and greater impairments of glucose and insulin in response to STZ (227)