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Cardiovascular risk assessment has evolved substantially over the past decades

Patients had type 2 diabetes with NO other anti-diabetic agents allowed for at least 90 days prior to the trial

It is also noteworthy that central GLP-1R signaling appears to be impaired in chronic stress conditions or under the influence of a high concentration of glucocorticoids, often observed in patients with depression

But it also means many people eat less food overall, skip meals more often, or struggle to tolerate larger meals

In fact, the American Journal of Clinical Nutritions 2025 consensus paper found that pairing these medications with targeted nutrition and exercise is critical to preserve lean muscle mass, maintain gut health, and achieve and maintain long term results