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In contrast, when T-cells derived from individuals with lung carcinoma and those undergoing stress were treated with dopamine, it significantly inhibited the proliferation of human CD4 + and CD8 + T-cells and significantly reduced CD8 + T-cell cytotoxicity through D1-mediated cAMP signaling (Saha, Mondal, Basu et al., 2001, Saha, Mondal, Majumder et al., 2001)

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