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In: McManus LM, Mitchell RN (eds) Pathobiology of Human Disease

The kidney is regulated by the autonomic nervous system and rhythmic entrainment signals

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In the Phase 2 trial, retatrutide was administered as a once-weekly subcutaneous injection an approach consistent with other incretin-based therapies in this class

236 SCFAs in the gut-brain axis SCFAs as gut bacteria-derived metabolites are transported from the gut to the CNS, cross the BBB with the bloodstream, 237 and act as signals to affect host metabolism and immunity reaction, which has a substantial impact on human physical and mental health