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Validation studies showed that the absolute biases for the quality control (QC) samples at the low, medium and high levels were 0.6%, 5.0% and 5.6% in plasma, and 4.6%, 9.0% and 7.0% in urine, respectively

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In this case, heterogeneity was categorized as low, moderate, or high for I 2 values of 25%, 50%, and 75%, respectively, and the chi-square test was considered statistically significant with a P value of T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk

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