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Studies found that 40 to 59 per cent of B12 in meat, fish and cows milk is degraded during cooking (Rizzo et al., 2016
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Several factors can impair B12 absorption: Reduced stomach acid production (achlorhydria or hypochlorhydria), common in older adults and those taking proton pump inhibitors or H2-receptor antagonists long-term, impairs the release of B12 from food proteins Pernicious anaemia , an autoimmune condition destroying parietal cells and reducing intrinsic factor production, completely blocks the primary absorption pathway Gastrointestinal disorders including Crohn's disease, coeliac disease, or surgical removal of stomach or ileum sections directly damage absorption sites Metformin , commonly prescribed for type 2 diabetes, may reduce B12 absorption through unclear mechanisms
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Preserved lean muscle mass while reducing fat mass Studies showed that NNMT inhibition selectively reduced adipose tissue without negative effects on skeletal muscle mass, suggesting a favorable body composition profile
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