Milk thistle helps to create glutathione in the liver, an antioxidant that neutralizes free radicals effecting not only the liver, but according to certain research, also may support the bladder, colon and skin cells as well
The rationale behind this phenomenon pertains to the function of CAFs in regulating ECM remodelling within the TME
Thanks to its sticky sulfur component, glutathione plays a key role in the removal of several toxins, by acting as a conjugate that attaches to those small molecules and enables their excretion through bile
It stabilizes cellular membranes, protects against oxidative stress, and supports mitochondrial function
H3K27me3 and H3K4me3 can co-occupy the same promoters and such bivalent chromatin structure is thought to allow fast activation of gene expression (Bernstein et al., 2006