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The results of immunofluorescence staining of the synovial tissues indicated that, compared with the NC group, the proportion of CD68 + CD86+ M1 macrophages significantly increased in the RA group, while the proportion of CD68 + CD206+ M2 macrophages did not change significantly

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No obstante, fue en 2021 cuando la Administracin de Alimentos y Medicamentos de Estados Unidos (FDA, por sus siglas en ingls) aprob Wegovy (semaglutida, Novo Nordisk) para el tratamiento de la obesidad

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