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A side effect that occurs in 0.1% of patients (1 in 1,000) has only a 28% chance of appearing in a 338-person trial

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The signal was real but messy, confounded by weight loss, blood pressure changes, and improved cardiovascular function

Side effects were consistent with those seen for obesity therapies, including gastrointestinal symptoms (nausea, diarrhea and constipation) and an elevated rate of dysesthesia (abnormal skin sensations), reported in about 20.9% of patients on the highest dose

The gut, in particular, contains the highest density of immune cells in the body and acts as a major inflammatory signaling hub