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First, AOD-9604 activates beta-3 adrenergic receptors on fat cells, triggering the cAMP-PKA cascade that activates hormone-sensitive lipase

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Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis

EDR did not produce the same reported proliferative or secretory-marker effect as AEDG in that experiment

This increases the risk of liver injury