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For patients interested in participating in research , the following resources may be helpful: NIHR Be Part of Research (bepartofresearch.nihr.ac.uk) search for Parkinson's and GLP-1 trials Parkinson's UK (www.parkinsons.org.uk) information on current research and trial opportunities When to contact your GP or specialist : If you have Parkinson's disease and diabetes, and wish to discuss whether a GLP-1 receptor agonist is appropriate for your diabetes management If you experience new or worsening symptoms whilst taking any medication If you are interested in clinical trial participationyour neurologist can advise on suitable studies Seek urgent medical attention if you experience: Severe, persistent abdominal pain (possible pancreatitis) Persistent vomiting or inability to keep fluids down (risk of dehydration) Signs of dehydration (extreme thirst, dark urine, dizziness) Allergic reaction (rash, swelling, difficulty breathing) Patients should never start, stop, or modify medications without medical supervision
Do not take GLP-1 Medications if you are a Type I Diabetic on Insulin, family history of Medullary Thyroid Carcinoma (MTC), Multiple Endocrine Neoplasia 2 (MEN2), history of Pancreatitis or Gastroparesis (stomach paralysis), Pregnant, Breastfeeding, or a Type II Diabetic taking another GLP-1 Medication (Victoza, Trulicity, etc.), Chronic Kidney Disease
Subsequent target gene network analysis revealed the significant enrichment of genes in transcriptional activation and neuron and axon projections, preferentially in ASD-related subjects that are associated with neurodevelopment, among which are the Fragile X Mental Retardation (FMR) 1 and Forkhead Box Protein (FOXP) 2 [171]
Researchers utilise this compound in laboratory models to investigate cellular energy homeostasis and NAD+ salvage pathways
