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The FDA approval of bortezomib in 2003 for multiple myeloma marked a paradigm shift in targeted cancer therapy

This is a genuine structural failure that goes beyond what biology alone can bridge

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Glutathione therapeutics As an increase in GSH appears to be a ubiquitous response to oxidants and electrophiles and some diseases appear to be exacerbated by decreasing GSH, increasing GSH by using delivery of permeable esters (Levy et al., 1993) or increasing the availability of cysteine using the non-toxic precursor N-acetylcysteine (Thor et al., 1979) have been proposed

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